SCIENTIFIC PURSUITS
We are a laboratory dedicated to the characterization and the cure of neurodegenerative disease.
The Sardiello lab uses genetics, cell biology and systems biology approaches to study how the cell regulates its metabolic programs and how dysfunctions in these programs lead to neurological disease. Our ultimate goal is to translate our knowledge of these regulatory networks into therapeutic approaches for neurodegenerative disorders.
L E A R N M O R E >
We are a laboratory dedicated to the characterization and the cure of neurodegenerative disease.
The Sardiello lab uses genetics, cell biology and systems biology approaches to study how the cell regulates its metabolic programs and how dysfunctions in these programs lead to neurological disease. Our ultimate goal is to translate our knowledge of these regulatory networks into therapeutic approaches for neurodegenerative disorders.
L E A R N M O R E >
R E C E N T N E W S
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Juvenile Batten Disease- A Problem with Cellular Waste Management
March 29, 2017 Like a large dynamic city, a cell carries out many activities that generate waste. Waste needs to be disposed of properly in order for the city to continue its activities without interruption. If waste management fails, waste progressively accumulates and eventually leads to interruption and paralysis of the activities of the city. Something similar happens in the human brain when cellular waste is not discarded. Juvenile Batten disease is one of nearly 50 human cellular waste storage disorders... fromthelabs.bcm.edu/2017/03/29/juvenile-batten-disease-a-problem-with-cellular-waste-management/ |
Image of the Month: Mouse brain with Batten disease
May 1, 2017 Juvenile Batten disease is one of nearly 50 human cellular waste storage disorders. In the Sardiello lab, researchers use genetics, cell biology and systems biology approaches to investigate how cells regulate their metabolic programs and how dysfunction of these programs can lead to neurological disease. “In juvenile Batten disease, the function of brain cells is progressively affected by the accumulation of cellular waste... fromthelabs.bcm.edu/2017/05/01/image-of-the-month-mouse-brain-with-batten-disease/ |
Houston researchers racing to develop treatment to save Woodlands teen
October 11, 2016 Six years ago, doctors told Missy and Wayne Herndon their 6-year-old son had a rare genetic disorder. The boy would soon be blind, they said. Cognitive ability would go next, slowly over time. And then, probably in his teen years, Will would die. There was no cure or even research money for Batten disease, a condition affecting fewer than 1,000 children across the world. Nothing to be done, doctors said, but wait... www.chron.com/local/prognosis/article/Houston-researchers-racing-to-develop-treatment-9960609.php |