SCIENTIFIC GOALS AND PURSUITS
We are a laboratory dedicated to the characterization and the cure of neurodegenerative disease.
The Sardiello lab uses genetics, cell biology and systems biology approaches to study how the cell regulates its metabolic programs and how dysfunctions in these programs lead to neurological disease. Our ultimate goal is to translate our knowledge of these regulatory networks into therapeutic approaches for neurodegenerative disorders.
We are a laboratory dedicated to the characterization and the cure of neurodegenerative disease.
The Sardiello lab uses genetics, cell biology and systems biology approaches to study how the cell regulates its metabolic programs and how dysfunctions in these programs lead to neurological disease. Our ultimate goal is to translate our knowledge of these regulatory networks into therapeutic approaches for neurodegenerative disorders.
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Medical Genetics is the main focus of our lab. Working on the foundation that the Human Genome Project has built, we are constantly trying to characterize un-annotated genes and proteins that are associated with hereditary disorders. |
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Lysosomes have always been a focused part of our research- characterizing lysosomal proteins can help us discover ways to fight back against lysosomal storage neurodegenerative diseases. Dr. Sardiello characterized TFEB (Transcription Factor EB) in 2009, with a groundbreaking study which refined the role of lysosomes. Since then, the Sardiello lab has been dedicated towards understanding lysosomal protein in an effort to cure or treat Neuronal Ceroid Lipofuscinoses, a specific category of lysosomal storage diseases. |
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Translational Medicine is one of our lab's biggest priorities. We believe strongly in bench-to-bedside approaches, and work hard to fulfill that ideal. Much of our research is focused on not only characterizing and discovering new scientific concepts, but also on how to deliver the fruit of our discoveries to the patients that need it. The Sardiello Lab is here to help. |