THE SARDIELLO LABORATORY
  • Home
  • People
    • Principal Investigator >
      • Marco Sardiello
    • Postdoctoral Associates >
      • Parisa Lotfi
      • Jaiprakash Sharma
      • Pal Rituraj
    • Graduate Students >
      • Abdallah Amawi
      • Yan Xiong
    • Staff
    • Undergraduate Students >
      • Kevin Chang
    • Former Members >
      • Alberto di Ronza
      • Lakshya Bajaj
      • Michela Palmieri
      • Chong Kun Cheon
      • Junyan Guo
      • Deepthi Sanagasetti
  • Our Research
  • Publications
  • Sponsors
  • Contact

P U B L I C A T I O N S

2018
Chang, K.T., Guo, J., di Ronza, A. and Sardiello, M., 2018. Aminode: Identification of Evolutionary Constraints in the Human Proteome. Scientific Reports, 8(1), p.1357.

2017

Pal, R., Bondar, V.V., Adamski, C.J., Rodney, G.G. and Sardiello, M., 2017. Inhibition of ERK1/2 Restores GSK3β Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis. Scientific reports, 7(1), p.4174.

Palmieri, M., Pal, R. and Sardiello, M., 2017. AKT modulates the autophagy-lysosome pathway via TFEB. 
Cell Cycle, 16(13), pp.1237-1238.

Palmieri, M., Pal, R., Nelvagal, H.R., Lotfi, P., Stinnett, G.R., Seymour, M.L., Chaudhury, A., Bajaj, L., Bondar, V.V., Bremner, L. and Saleem, U.,... Sardiello, M., 2017. mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases. Nature Communications, 8, p.14338.
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2016
Pal, R., Bajaj, L., Sharma, J., Palmieri, M., Di Ronza, A., Lotfi, P., Chaudhury, A., Neilson, J., Sardiello, M. and Rodney, G.G., 2016. NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson’s disease. Scientific reports, 6.

Bouché, V., Espinosa, A.P., Leone, L., Sardiello, M., Ballabio, A. and Botas, J., 2016. Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway. Autophagy, 12(3), pp.484-498.

Sardiello, M., 2016. Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases. Annals of the New York Academy of Sciences, 1371(1), pp.3-14.

2015
Dennis, Y.T., Lotfi, P., Simons, D.L., Sardiello, M. and Wu, S.M., 2015. Electrophysiological and histological characterization of rod-cone retinal degeneration and microglia activation in a mouse model of mucopolysaccharidosis type IIIB. Scientific reports, 5.

Tian, X., Gala, U., Zhang, Y., Shang, W., Jaiswal, S.N., di Ronza, A., Jaiswal, M., Yamamoto, S., Sandoval, H., Duraine, L. and Sardiello, M., 2015. A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PLoS Biol, 13(3), p.e1002103.

Ohkubo, K., Sakai, Y., Inoue, H., Akamine, S., Ishizaki, Y., Matsushita, Y., Sanefuji, M., Torisu, H., Ihara, K., Sardiello, M. and Hara, T., 2015. Moyamoya disease susceptibility gene RNF213 links inflammatory and angiogenic signals in endothelial cells. Scientific reports, 5, p.13191.

Wong, C.O., Palmieri, M., Li, J., Akhmedov, D., Chao, Y., Broadhead, G.T., Zhu, M.X., Berdeaux, R., Collins, C.A., Sardiello, M. and Venkatachalam, K., 2015. Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction. Cell reports, 12(12), pp.2009-2020.

2014
Pal, R., Palmieri, M., Loehr, J.A., Li, S., Abo-Zahrah, R., Monroe, T.O., Thakur, P.B., Sardiello, M. and Rodney, G.G., 2014. Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy. Nature communications, 5, p.4425.

Pal, R., Monroe, T.O., Palmieri, M., Sardiello, M. and Rodney, G.G., 2014. Rotenone induces neurotoxicity through Rac1‐dependent activation of NADPH oxidase in SHSY‐5Y cells. FEBS letters, 588(3), pp.472-481.

Song, W., Wang, F., Lotfi, P., Sardiello, M. and Segatori, L., 2014. 2-Hydroxypropyl-β-cyclodextrin Promotes Transcription Factor EB-mediated Activation of Autophagy IMPLICATIONS FOR THERAPY. Journal of Biological Chemistry, 289(14), pp.10211-10222.

Polito, V.A., Li, H., Martini‐Stoica, H., Wang, B., Yang, L., Xu, Y., Swartzlander, D.B., Palmieri, M., Di Ronza, A., Lee, V.M.Y. and Sardiello, M., 2014. Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO molecular medicine, 6(9), pp.1142-1160.

Gao, J., Schatton, D., Martinelli, P., Hansen, H., Pla-Martin, D., Barth, E., Becker, C., Altmueller, J., Frommolt, P., Sardiello, M. and Rugarli, E.I., 2014. CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear-encoded mitochondrial proteins. J Cell Biol, 207(2), pp.213-223.

2013
Song, W., Wang, F., Savini, M., Ake, A., Di Ronza, A., Sardiello, M. and Segatori, L., 2013. TFEB regulates lysosomal proteostasis. Human molecular genetics, p.ddt052.

Mauri, V., Lotfi, P., Segatori, L. and Sardiello, M., 2013. A rapid and sensitive method for measuring N-acetylglucosaminidase activity in cultured cells. PLOS one, 8(6), p.e68060.

2012
​Gennarino, V.A., D'Angelo, G., Dharmalingam, G., Fernandez, S., Russolillo, G., Sanges, R., Mutarelli, M., Belcastro, V., Ballabio, A., Verde, P. and Sardiello, M., 2012. Identification of microRNA-regulated gene networks by expression analysis of target genes. Genome research, 22(6), pp.1163-1172.

2011
Settembre, C., Di Malta, C., Polito, V.A., Arencibia, M.G., Vetrini, F., Erdin, S., Erdin, S.U., Huynh, T., Medina, D., Colella, P. and Sardiello, M., 2011. TFEB links autophagy to lysosomal biogenesis. Science, 332(6036), pp.1429-1433.

Gennarino, V.A., Sardiello, M., Mutarelli, M., Dharmalingam, G., Maselli, V., Lago, G. and Banfi, S., 2011. HOCTAR database: a unique resource for microRNA target prediction. Gene, 480(1), pp.51-58.

Medina, D.L., Fraldi, A., Bouche, V., Annunziata, F., Mansueto, G., Spampanato, C., Puri, C., Pignata, A., Martina, J.A., Sardiello, M. and Palmieri, M., 2011. Transcriptional activation of lysosomal exocytosis promotes cellular clearance. Developmental cell, 21(3), pp.421-430.

Palmieri, M., Impey, S., Kang, H., di Ronza, A., Pelz, C., Sardiello, M. and Ballabio, A., 2011. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Human molecular genetics, 20(19), pp.3852-3866.

2009
Sardiello, M., Palmieri, M., di Ronza, A., Medina, D.L., Valenza, M., Gennarino, V.A., Di Malta, C., Donaudy, F., Embrione, V., Polishchuk, R.S. and Banfi, S., 2009. A gene network regulating lysosomal biogenesis and function. Science, 325(5939), pp.473-477.
<PUBMED> 

Gennarino, V.A., Sardiello, M., Avellino, R., Meola, N., Maselli, V., Anand, S., Cutillo, L., Ballabio, A. and Banfi, S., 2009. MicroRNA target prediction by expression analysis of host genes. Genome research, 19(3), pp.481-490.

Sardiello, M. and Ballabio, A., 2009. Lysosomal enhancement: a CLEAR answer to cellular degradative needs.

2008
Roma, G., Sardiello, M., Cobellis, G., Cruz, P., Lago, G., Sanges, R. and Stupka, E., 2008. The UniTrap resource: tools for the biologist enabling optimized use of gene trap clones. Nucleic acids research, 36(suppl 1), pp.D741-D746.

Sardiello, M., Cairo, S., Fontanella, B., Ballabio, A. and Meroni, G., 2008. Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties. BMC evolutionary biology, 8(1), p.225.

Spatuzza, C., Schiavone, M., Di Salle, E., Janda, E., Sardiello, M., Fiume, G., Fierro, O., Simonetta, M., Argiriou, N., Faraonio, R. and Capparelli, R., 2008. Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk. Nucleic acids research, 36(13), pp.4402-4416.

2007
Roma, G., Cobellis, G., Claudiani, P., Maione, F., Cruz, P., Tripoli, G., Sardiello, M., Peluso, I. and Stupka, E., 2007. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Genome research, 17(7), pp.1051-1060.

2005
Cobellis, G., Nicolaus, G., Iovino, M., Romito, A., Marra, E., Barbarisi, M., Sardiello, M., Di Giorgio, F.P., Iovino, N., Zollo, M. and Ballabio, A., 2005. Tagging genes with cassette-exchange sites. Nucleic acids research, 33(4), pp.e44-e44.

Sardiello, M., Tripoli, G., Romito, A., Minervini, C., Viggiano, L., Caggese, C. and Pesole, G., 2005. Energy biogenesis: one key for coordinating two genomes. Trends in genetics, 21(1), pp.12-16.

Sardiello, M., Annunziata, I., Roma, G. and Ballabio, A., 2005. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Human molecular genetics, 14(21), pp.3203-3217.

2003
Sardiello, M., Licciulli, F., Catalano, D., Attimonelli, M. and Caggese, C., 2003. MitoDrome: a database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. Nucleic acids research, 31(1), pp.322-324.

Sardiello, M., Tripoli, G., Oliva, M., Santolamazza, F., Moschetti, R., Barsanti, P., Lanave, C., Caizzi, R. and Caggese, C., 2003. A comparative study of the porin genes encoding VDAC, a voltage-dependent anion channel protein, in Anopheles gambiae and Drosophila melanogaster. Gene, 317, pp.111-115.
​

THE SARDIELLO LAB

Contact Information
  • Home
  • People
    • Principal Investigator >
      • Marco Sardiello
    • Postdoctoral Associates >
      • Parisa Lotfi
      • Jaiprakash Sharma
      • Pal Rituraj
    • Graduate Students >
      • Abdallah Amawi
      • Yan Xiong
    • Staff
    • Undergraduate Students >
      • Kevin Chang
    • Former Members >
      • Alberto di Ronza
      • Lakshya Bajaj
      • Michela Palmieri
      • Chong Kun Cheon
      • Junyan Guo
      • Deepthi Sanagasetti
  • Our Research
  • Publications
  • Sponsors
  • Contact